Immuno-Oncology - Gene and Immunotherapy
Chimeric antigen receptor (CAR) T-cell immunotherapy is a rapidly growing personalized treatment which expands native cellular products ex vivo for re-infusion into patients. This therapeutic approach turns the immune system’s cancer-fighting cells into better defenders by either increasing their fighting ability or their numbers. However, the construct and vector used sometimes necessitates custom assay design for immunogenicity assessment of humoral or cellular-type responses.
Analytical methods applicable to CAR T-Cell Therapy development for assessing transduction, persistence & cytokine response syndrome:
Immuno modulation with cancer vaccines is another powerful therapeutic development that shows potential as both a standalone treatment and in combination with other immunotherapies. As with other ITs, the clinical assessments for cancer vaccines include toxicological testing(especially immunogenicity and immune monitoring for safety and efficacy). Our experts can provide assay development and testing solutions for these clinical evaluation needs.