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What is TMA?

Thrombotic microangiopathies (TMA) are a category of diseases linked by endothelial injury leading to aggregation of platelets on the damaged endothelium, microvascular thrombosis and organ dysfunction related to microvascular injury.

Transplant-associated thrombotic microangiopathy (TA-TMA) occurs when endothelial injury in the context of allogeneic hematopoietic cell transplantation (allo-HCT) causes microangiopathic hemolytic anemia and platelet consumption, resulting in microvascular thrombosis and fibrin deposition in the microcirculation.

Transplant-associated thrombotic microangiopathy (TA-TMA) is a complication of stem cell transplants that can occur with peripherally mobilized stem cells or bone marrow-derived stem cells.

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Next Day Results for sC5b-9, CH50 and Eculizumab

Get comprehensive results with the fastest turn around time...anywhere.

Eurofins Viracor's TA-TMA testing stands out for its comprehensiveness, offering clinicians a complete assessment of complement pathway regulation and potential deregulation with validated assays for Eculizumab, CH50, and sC5b-9. Our comprehensive approach ensures that clinicians receive detailed results across all three critical areas, empowering them to make informed decisions about patient treatment promptly, thanks to our industry-leading 24 hour turnaround time.

Transplant Associated Thrombotic MicroAngiopathy

How Does TMA Occur?

Transplant-associated thrombotic microangiopathy (TA-TMA) occurs when endothelial injury in the context of allogeneic hematopoietic cell transplantation (allo-HCT) causes microangiopathic hemolytic anemia and platelet consumption, resulting in microvascular thrombosis and fibrin deposition in the microcirculation.

 

How is it Diagnosed?

CBC & Schistocyte Smear

LDH & Haptoglobin

PT, Aptt & Fibrinogen

DCT

Serum C5b9

Work up for Viral Infections

Urine for Proteinuria

TA-TMA Transplant-associated thrombotic microangiopathy

TA-TMA Testing: Faster Results and a Comprehensive Approach

 

Eurofins Viracor's TA-TMA (Transplant-associated thrombotic microangiopathy) testing stands out for its comprehensiveness, offering clinicians a complete assessment of complement pathway regulation and potential deregulation with validated assays for Eculizumab, CH50, and sC5b-9.

  • Eculizumab
  • CH50
  • sC5b-9

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